Congenital Hypothyroidism
High performance, reliable CHscreening toolsThe
analytical sensitivity of PerkinElmer'sNeonatal TSH assay is 2
μU/mL and thatof T4 is 1.5 μg/dL. Intra-assay imprecisionfor
TSH is close to 6%, while for T4 it is10% using AutoDELFIA and 6%
using themanual DELFIA platform. All calibratorsand controls are
lot-specifi c to ensure thatevery lot is of the same high
standard.On both platforms and with both assays,PerkinElmer has
taken every step neededto assure the highest standards of
reliabilityand safety in screening for CH.
AutoDELFIA® TSH and T4 -assays - a robust,
costeffective solutionThe AutoDELFIA fully automatedsystem
allows for sensitive and specifi cquantitation of TSH and T4 in
dried bloodsamples, and brings robustness, reliabilityand
cost-effectiveness to yourCH screening program.
Early diagnosis for healthy lifeSevere congenital
hypothyroidism canbe found in 1 in 4000 newborns whilethe milder
forms are more frequent. CHresults from a failure of the thyroid
glandsto produce thyroid hormones in adequateamounts. The condition
can easily betreated with daily doses of thyroxine butclinical
diagnosis is diffi cult to establish andthe disease may continue
unrecognizedfor a long time causing irreversible braindamage.
However, increased TSH anddecreased T4 are clear signs of CH,
whichhave led to the establishment of large scalescreening
programs.PerkinElmer's Neonatal TSH and T4 assaysare used with
dried blood spot specimensas an aid in screening newborns
forcongenital hypothyroidism.
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